Flea medicine for dogs and cats that starts killing fleas in just 30 minutes

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Comfortis® (spinosad) is a fast, safe and effective flea treatment for flea infestations on your dog or cat. It starts killing fleas faster than Nexgard® (afoxolaner)3,* and killed 100% of fleas on dogs and 98% of fleas on cats in just four hours in controlled laboratory studies.

*Data from two laboratory studies conducted in different locations using different dogs and strains of fleas.


Important Safety Information

The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are: depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures.

Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, incoordination, excessive dilation of pupils, blindness and disorientation. Post-approval experience continues to support the safety of Comfortis when used concurrently with heartworm preventatives according to label directions.

Use with caution in breeding females and dogs with pre-existing epilepsy. The safe use of Comfortis in breeding males has not been evaluated. See the label for complete safety information.

Comfortis is approved for use in cats 14 weeks of age or older and 2 pounds of body weight or greater and dogs 14 weeks of age or older and 3.3 pounds of body weight or greater.


Available in 5 different dosages

  • Pink: Dogs 2.3kg – 4.5kg or Cats 1.4kg – 2.7kg
  • Orange: Dogs 4.6kg – 9kg or Cats 2.8kg – 5.4kg
  • Green: Dogs 9.1kg – 18kg or Cats 5.5kg – 11.2kg
  • Blue: Dogs 18.1kg – 27kg
  • Brown: Dogs 27.1kg – 54kg

Additional information


Pink (2.3-4.5kg), Orange (4.6-9kg), Green (9.1-18kg), Blue (18.1-27kg), Brown (27.1-54kg)